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Deep dive into key COVID-19 protein is step toward new drugs, vaccines（图）
COVID-19 protein step toward new drugs vaccines
2021/4/23
Researchers at Oregon State University have taken a key step toward new drugs and vaccines for combating COVID-19 with a detailed biophysical study of one protein's interactions with the SARS-CoV-2 ge...
Key Residues of the Receptor Binding Motif in the Spike Protein of SARS-CoV-2 That Interact With ACE2 and Neutralizing Antibodies
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds the host receptor angiotens...
SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells
SARS-CoV-2-encoded nucleocapsid protein acts viral suppressor of RNA interference cells
2020/6/12
We thank Prof. Peng Zhou (Wuhan, China) for kindly providing materials and thank Yan Wu and Weijuan Shang for experimental assistance. This work was supported by the Strategic Priority Research Progra...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein
Fusion mechanism 2019-nCoV inhibitors targeting HR1 domain spike protein
2020/6/12
Very recently, a novel coronavirus, 2019-nCoV, emerged in Wuhan, China and then quickly spread worldwide, resulting in >17,388 confirmed cases and 361 deaths as of 3 February 2020, thus calling for th...
期刊信息
篇名
Identification of a Tobacco Protein Interacting with Tomato Mosaic Virus Coat Protein and Facilitating Long-Distance Movement of virus epted by Archives of virology .(2005)
语种
英文
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撰写
作者
L...
OspA Sequence Comparison and Protection Against Borrelia burgdorferi Infection in Gerbils by Recombinant OspA Protein
Borrelia burgdorferi Linear and circular plasmid Outer surface protein A (OspA) Recombinant protein
2010/2/8
Lyme borreliosis is a tick-born disease caused by the spirochete Borrelia burgdorferi. The aim of this research was molecular typing of different strains of B. burgdorferi and protective efficacy of o...
Evaluation of a Native Preparation of HCV Core Protein (2-122) For Potential Applications in Immunization, Diagnosis and Mab Production
Hepatitis C HCV core protein Monoclonal antibody Total core Ag Iran
2010/2/3
Infection with hepatitis C virus (HCV) is a worldwide problem. Among HCV proteins, core antigen (Ag), besides its importance for diagnostic application is a prime candidate for component of a vaccine....