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Researchers Use DNA‘Clews’to Shuttle CRISPR-Cas9 Gene-Editing Tool into Cells
Researchers DNA Clews Shuttle CRISPR-Cas9 Gene-Editing Tool
2015/9/8
CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...
How DNA ‘Proofreader’ Proteins Pick and Edit Their Reading Material
DNA Proofreader Proteins Pick Reading Material
2015/9/9
DNA mismatch repair (MMR) identifies and corrects errors made during replication. In all organisms except those expressing MutH, interactions between a DNA mismatch, MutS, MutL, and the replication pr...
人造碱基能像天然DNA那样连接
人造碱基能 天然DNA
2015/6/11
美国印第安纳大学和应用分子进化基金会等机构科学家证明,他们造出的两种人造DNA“字母”Z和P,能像天然DNA那样组合连接在一起,将来有望把这两个新成员纳入到活细胞中。相关论文发表在最近的《美国化学协会会刊》(JACS)上。合成生物学家一直在竞相研究遗传基本单位的人造版。美国应用分子进化基金会的斯蒂芬·本纳说:“从根本上说,我们一直在自下而上地重新发明‘遗传字母表’。” 从新药开发到人造生命,这些人...
可销毁特定DNA序列装置出炉
CRISPR技术 DNA分子
2015/5/21
英国《自然·通讯》杂志19日在线发表了一篇合成生物学论文,描述了一种基于“基因组编辑”CRISPR技术的的装置,能销毁转基因生物中特定的DNA序列。控制住特定DNA序列销毁的能力,其应用范围将包括防止转基因生物的环境释放、帮助生物技术公司保护知识产权以及避免偷窃等等。
New form of DNA modification may carry inheritable information
DNA modification carry inheritable information
2015/5/25
Scientists at the University of Chicago, Harvard University and the Chinese Academy of Sciences have described the surprising discovery and function of a new DNA modification in insects, worms and alg...
New lab technique simultaneously reveals structure and function of proteins critical in DNA repair
structure and function proteins critical DNA repair
2015/4/29
By combining two highly innovative experimental techniques, scientists at the University of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlate...
Damaged DNA may stall patrolling molecule to initiate repair(图)
Damaged DNA stall patrolling molecule initiate repair
2015/3/4
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The findi...
CHAMPAIGN, Ill. — When munched by grazing animals (or mauled by scientists in the lab), some herbaceous plants overcompensate – producing more plant matter and becoming more fertile than they otherwis...
欧盟科学家研究蝙蝠DNA揭示细胞老化机理
欧盟科学家 蝙蝠DNA 细胞老化机理
2014/11/3
蝙蝠(Bats)昼伏夜出的生活习性及其丑陋外观另人厌恶,特别是非洲最近流行的埃博拉病毒据称由蝙蝠传播引起,更让人对蝙蝠产生恐惧。然而,蝙蝠作为唯一可持续飞行的哺乳类物种,部分蝙蝠甚至一夜间可飞行1000公里,具有其它哺乳类动物无法比拟的优势。一般情况下,哺乳动物的预期寿命同其身体质量成正比,体型愈小的哺乳动物由于细胞更高的新陈代谢率其预期寿命愈短,但蝙蝠例外。同类体型的野生鼠类寿命一般1至2年,但...
Charged graphene gives DNA a stage to perform molecular gymnastics(图)
DNA molecular gymnastics
2014/12/1
CHAMPAIGN, Ill. — When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they did not know they were about to witness a display of molecul...
Finding supports model on cause of DNA's right-handed double helix(图)
The double helix structure Cosmic ray electrons Bolt Nut Screw Nano Molecular physics DNA
2014/10/9
The DNA of every organism on Earth is a right-handed double helix, but why that would be has puzzled scientists since not long after Francis Crick and James Watson announced the discovery of DNA's dou...
Researchers from North Carolina State University, Duke University and the University of Copenhagen have created the world’s largest DNA origami, which are nanoscale constructions with applications ran...
The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous ...
Researchers develop models to study polyelectrolytes, including DNA and RNA(图)
DNA RNA polyelectrolytes
2014/8/26
Researchers from North Carolina State University have developed a novel and versatile modeling strategy to simulate polyelectrolyte systems. The model has applications for creating new materials as we...
Dating and DNA show Paleoamerican-Native American connection
Dating and DNA Paleoamerican-Native American connection
2014/6/12
UNIVERSITY PARK, Pa. -- Eastern Asia, Western Asia, Japan, Beringia and even Europe have all been suggested origination points for the earliest humans to enter the Americas because of apparent differe...