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CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein...
DNA mismatch repair (MMR) identifies and corrects errors made during replication. In all organisms except those expressing MutH, interactions between a DNA mismatch, MutS, MutL, and the replication pr...
美国印第安纳大学和应用分子进化基金会等机构科学家证明,他们造出的两种人造DNA“字母”Z和P,能像天然DNA那样组合连接在一起,将来有望把这两个新成员纳入到活细胞中。相关论文发表在最近的《美国化学协会会刊》(JACS)上。合成生物学家一直在竞相研究遗传基本单位的人造版。美国应用分子进化基金会的斯蒂芬·本纳说:“从根本上说,我们一直在自下而上地重新发明‘遗传字母表’。” 从新药开发到人造生命,这些人...
英国《自然·通讯》杂志19日在线发表了一篇合成生物学论文,描述了一种基于“基因组编辑”CRISPR技术的的装置,能销毁转基因生物中特定的DNA序列。控制住特定DNA序列销毁的能力,其应用范围将包括防止转基因生物的环境释放、帮助生物技术公司保护知识产权以及避免偷窃等等。
Scientists at the University of Chicago, Harvard University and the Chinese Academy of Sciences have described the surprising discovery and function of a new DNA modification in insects, worms and alg...
By combining two highly innovative experimental techniques, scientists at the University of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlate...
Sites where DNA is damaged may cause a molecule that slides along the DNA strand to scan for damage to slow on its patrol, delaying it long enough to recognize and initiate repair. The findi...
CHAMPAIGN, Ill. — When munched by grazing animals (or mauled by scientists in the lab), some herbaceous plants overcompensate – producing more plant matter and becoming more fertile than they otherwis...
蝙蝠(Bats)昼伏夜出的生活习性及其丑陋外观另人厌恶,特别是非洲最近流行的埃博拉病毒据称由蝙蝠传播引起,更让人对蝙蝠产生恐惧。然而,蝙蝠作为唯一可持续飞行的哺乳类物种,部分蝙蝠甚至一夜间可飞行1000公里,具有其它哺乳类动物无法比拟的优势。一般情况下,哺乳动物的预期寿命同其身体质量成正比,体型愈小的哺乳动物由于细胞更高的新陈代谢率其预期寿命愈短,但蝙蝠例外。同类体型的野生鼠类寿命一般1至2年,但...
CHAMPAIGN, Ill. — When Illinois researchers set out to investigate a method to control how DNA moves through a tiny sequencing device, they did not know they were about to witness a display of molecul...
The DNA of every organism on Earth is a right-handed double helix, but why that would be has puzzled scientists since not long after Francis Crick and James Watson announced the discovery of DNA's dou...
Researchers from North Carolina State University, Duke University and the University of Copenhagen have created the world’s largest DNA origami, which are nanoscale constructions with applications ran...
The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous ...
Researchers from North Carolina State University have developed a novel and versatile modeling strategy to simulate polyelectrolyte systems. The model has applications for creating new materials as we...
UNIVERSITY PARK, Pa. -- Eastern Asia, Western Asia, Japan, Beringia and even Europe have all been suggested origination points for the earliest humans to enter the Americas because of apparent differe...

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