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近期Cell杂志上发布了一项颠覆认知的新研究。来自美国西北大学的科学家们发现,降低果蝇的代谢水平可以避免某些突变表型的出现,甚至可以完全绕过致死突变的不利影响。该研究发现,降低代谢竟然能让完全没有microRNA的果蝇正常发育到成虫。论文作者表示:“这颠覆了我们所知的一切发育范式。”研究者提出,这是由于基因网络内部的“反馈控制”。当新陈代谢减缓,机体就有了更多的时间去纠正错误。这些基因突变的果蝇在...
近日,美国贝勒医学院及太平洋西北国家实验室的科学家们利用基因组蛋白组学相结合的分析技术首次对人类结肠癌的蛋白基因组进行了详尽的分析,全面剖析了结直肠癌相关生物标志物、药物靶点和肿瘤抗原,并在Cell杂志上发表题为“Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities”的文章。
2018年7月2日,The Plant Cell杂志在线发表了中国农业大学国家玉米改良中心田丰教授团队与杨小红教授团队合作题为“Genome-Wide Association Analyses Reveal the Importance of Alternative Splicing in Diversifying Gene Function and Regulating Phenotypic V...
Cells — the building blocks of our bodies — are encapsulated by membranes. The same goes for the specialized compartments within our cells.These membranes are extremely thin, oily films, containing pr...
Programming a molecular biology experiment can be similar to playing Sudoku; both are simple if you’re working with only a few molecules or a small grid, but they explode in complexity as they grow. N...
In a sharp and pointy world, wound healing is a critical and marvelous process.Despite a tremendous amount of scientific study, many outstanding mysteries still surround the way in which cells in livi...
While doing research at the Woods Hole Marine Biological Laboratory in Massachusetts, Sindy Tang learned of a remarkable organism: Stentor coeruleus. It’s a single-celled, free-living f...
Developing a superconducting computer that would perform computations at high speed without heat dissipation has been the goal of several research and development initiatives since the 1950s. Such a c...
Biologists have long known that bacteria grow faster and bigger when the quality of nutrients becomes better, a principle in microbial physiology known as the “growth law,” which describes the relatio...
In a major advance for fundamental biological research, UC San Francisco scientists have developed a tool capable of illuminating previously inscrutable cellular signaling networks that play a wide va...
On the surfaces of our trillions of cells is a complex crowd of molecules moving around, talking to each other, occasionally segregating themselves, and triggering basic functions ranging from pain se...
Scientists at Rutgers and other universities have created a new way to identify the state and fate of stem cells earlier than previously possible.Understanding a stem cell’s fate – the type...
New research out of Case Western Reserve University School of Medicine describes a mechanism by which an essential quality control system in cells identifies and destroys faulty genetic material. The ...
Phage therapy, which exploits the ability of certain viruses to infect and replicate within bacteria, shows promise for treating antibiotic-resistant bacterial infections.But the design of such therap...
This work compares the behavior of PC12 cells on planar and patterned III-nitride materials with nanostructured topographies. Three different materials’ compositions containing N-polar and Ga-polar ar...

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