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骨质疏松症一种以骨量低下、骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。大量研究证实,细胞外囊泡(EVs)在调控骨稳态的复杂机制中发挥重要的作用,这些囊泡在病理和生理环境中都起着至关重要的作用,而不同来源的EVs对骨质疏松症有明显且不同的影响。

近日,华西基础医学与法医学院刘肖珩教授团队在Bone Research发表原创研究论文,证实了基质囊泡来源的AnxA5在骨重塑中的重要作用,阐明了AnxA5通过促进基质囊泡与I型胶原的黏附,诱导骨前体细胞发生自噬和加速矿化预防骨丢失的新机制,为骨质疏松症的防治提供新策略。

西北工业大学生命学院骞爱荣教授团队主编《BONE CELL BIOMECHANICS, MECHANOBIOLOGY, AND BONE DISEASES》在爱思唯尔(ELSEVIER)出版集团正式出版(图)
骞爱荣 爱思唯尔 生物力学 骨疾病 骨细胞
2024/4/3

RNA nanoparticle therapy stops the spread of incurable bone marrow cancer(图)
RNA 纳米颗粒疗法 骨髓癌 肿瘤治疗
2023/6/27


Study:Changing the environment within bone marrow alters blood cell development
Changing the environment bone marrow blood cell development
2017/3/14
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.The findings, reported in th...
Silver Ion-Coated Medical Devices Could Fight MRSA While Creating New Bone
Silver Ion-Coated Medical Devices Fight MRSA Creating New Bone
2017/3/13
Methicillin-resistant Staphylococcus aureus (MRSA) infections are caused by a type of staph bacteria that has become resistant to the antibiotics used to treat ordinary staph infections. The rise of M...

The Story of a Bizarre Deep-sea Bone Worm Takes an Unexpected Twist(图)
Deep-sea Bone Worm Unexpected Twist
2014/12/30
The saga of the Osedax “bone-eating” worms began 12 years ago, with the first discovery of these deep-sea creatures that feast on the bones of dead animals. TheOsedax story grew even st...
By sorting human fat tissue cells by their expression of a certain gene, Brown University scientists were able to retrieve a high yield of cells that showed an especially strong propensity to make bon...
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated s...
Queensland child nutrition research boosted with new bone density technology
bone density technology child nutrition
2014/7/17
Research into improving outcomes for Queensland children whose skeletal health has been compromised by diseases such as cancer or cystic fibrosis and associated therapies will be advanced by a high-te...
"Development and Testing of Optic Probes for Transcutaneous Raman Spectroscopy Bone Diagnostic"
Optic Probes Transcutaneous Raman Spectroscopy Bone Diagnostic
2009/12/17
This project is for the development and testing of optic probes to be used in a novel biomedical imaging device for bone diagnostics. The fundamental technology, Transcutaneous Raman Spectroscopy (TRS...

Cut marks on bone suggest burial rituals of Early Britons(图)
bone burial rituals Early Britons the Mesolithic period
2009/8/10
Research on human remains from Kent’s Cavern in Devon has led scientists to believe that humans from the Mesolithic period (after the Ice Age) may have engaged in complex ritualistic burial practices,...