搜索结果: 1-15 共查到“知识库 理学 Cancer”相关记录37条 . 查询时间(0.087 秒)
近日，皖南医学院第一附属医院神经系统疾病医学转化中心研究团队与新加坡国立大学杨潞龄医学院（NUS Yong Loo Lin School of Medicine）Chen Xiaoyuan Shawn（陈小元）教授团队、东南大学中大医院生命健康高等研究院夏洪平教授团队紧密合作，在《Nature Cancer》发表了题为“An in vitro-transcribed circular RNA ta...
肿瘤学顶级期刊《Clinical Cancer Research》（影响因子13.801；17/245，Oncology，Q1）近日在线发表北京航空航天大学医学科学与工程学院，生物医学工程高精尖创新中心于健教授团队、陈伟副教授团队及北京高博博仁医院克晓燕、胡凯主任团队合作的最新研究成果“Single-cell transcriptomics reveals immune reconstitutio...
Cancer Immunol. Res.|上海市免疫学研究所王锋团队解析TCR复合体信号机制，开发增强型TCR-T免疫治疗新策略（图）
细胞膜 细胞活化 酪氨酸 上海市免疫学研究所
2023/4/12
TCR作为T细胞活化的第一信号通过识别抗原-MHC启动跨膜信号，触发位于CD3胞质段（cytoplasmic domain, CD3CD）的免疫受体酪氨酸激活基序（immunoreceptor tyrosine-based activation motifs, ITAMs）磷酸化，从而激活T细胞下游的系列反应介导特异性免疫应答。
选择性多聚腺苷酸化 (Alternative polyadenylation，APA) 是真核生物中普遍存在的一种转录调控机制，能调控基因互作和表达且广泛参与肿瘤发展1。研究团队已有研究揭示相比肿瘤样本，体外培养的癌细胞系整体基因的3’UTR缩短，并揭示了APA 的变化可以影响细胞对多种抗癌药物的敏感性，与癌症病人临床分期和预后等高度相关2。相关研究也揭示APA 参与调节各种免疫细胞的免疫反应，以...
徐建青/张晓燕团队在《Journal for ImmunoTherapy of Cancer》报道IL-21重组溶瘤痘苗病毒单独或联合免疫细胞疗法具有强效抗肿瘤作用（图）
溶瘤病毒 冷肿瘤 热肿瘤 牛痘病毒天坛株
2023/4/17
溶瘤病毒是天然的或经人工改造的、能在肿瘤组织中优势复制、直接或间接抑制肿瘤细胞生长的一类病毒。溶瘤病毒主要通过以下途径发挥抗肿瘤功能：（1）病毒在肿瘤细胞内复制导致肿瘤细胞直接杀伤；（2）病毒感染肿瘤细胞后激发并释放细胞因子，重塑肿瘤免疫微环境、趋化免疫细胞浸润到肿瘤组织，促进“冷肿瘤”向“热肿瘤”转变；（3）裂解的肿瘤细胞释放特异性抗原，与细胞因子协同，提升机体抗肿瘤特异性免疫反应；（4）溶瘤病...
树突状细胞（DC）疫苗是目前在临床上应用的一种肿瘤治疗疫苗，其制备过程一般都在病人体外进行，病人来源的DC在体外进行诱导分化后再回输给病人，这种疫苗制备过程十分复杂，容易被污染，不同的技术人员、不同条件的实验室制备的疫苗疗效差异较大，较难标准化，因此体外制备的DC疫苗很难在临床推广应用。
2020年4月16日，Journal for ImmunoTherapy of Cancer (JITC)杂志在线发表了上海交通大学医学院上海市免疫学研究所李斌课题组和复旦大学附属妇产科医院乳腺外科吴克瑾课题组合作的成果“Targeting ANXA1 abrogates Treg-mediated immune suppression in triple-negative breast canc...
Nutritional metabolomics and breast cancer risk in a prospective study
breast cancer diet nutrition metabolomics biomarker tocopherol alcohol androgen fat
2018/11/15
Background: The epidemiologic evidence for associations between dietary factors and breast cancer is weak and etiologic mechanisms are often unclear. Exploring the role of dietary biomarkers with meta...
Whole-grain intake and total, cardiovascular, and cancer mortality: a systematic review and meta-analysis of prospective studies
whole grain cardiovascular disease cancer mortality meta-analysis
2018/12/3
Background: The potential role of whole grain in preventing various mortality outcomes has been inconsistently reported in a wealth of prospective observational studies.
Lipid biomarkers and long-term risk of cancer in the Women’s Health Study
cancer lipids metabolomics triglycerides women
2018/11/30
Background: Lipid biomarkers, such as HDL-cholesterol concentrations, have been shown to have positive, inverse, and null associations with total, breast, and colorectal cancer risks. Studies of novel...
Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression
ERG protein expression TMPRSS2:ERG lycopene prostate cancer tomato sauce
2018/11/28
Background: There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention. Given their antioxidant properties...
Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort
breast cancer EPIC antioxidants carotenoids plasma
2018/11/27
Background: Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity.
Vegetable and fruit consumption and the risk of hormone receptor–defined breast cancer in the EPIC cohort
breast cancer estrogen receptor fruit progesterone receptor vegetables
2018/11/23
Background: The recent literature indicates that a high vegetable intake and not a high fruit intake could be associated with decreased steroid hormone receptor–negative breast cancer risk.
Inhibiting protein clearance to induce cell death in tuberous sclerosis and pancreatic cancer
Ral 4-phenylbutyric acid 4-PBA
2015/5/25
Sequestration at the aggresome and degradation through autophagy are two approaches by which a cell can counteract the toxic effect of misfolded proteins. Tuberous sclerosis (TS) and cancer cells can ...
Physical activity and all-cause mortality across levels of overall and abdominal adiposity in European men and women: the European Prospective Investigation into Cancer and Nutrition Study (EPIC)
cohort study epidemiology obesity physical activity exercise mortality population attributable fraction
2018/12/24
Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity c...