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A human neutralizing antibody targets the receptor binding site of SARS-CoV-2
Preventive medicine SARS-CoV-2 Viral infection
2020/6/11
An outbreak of the coronavirus disease 2019 (COVID-19)1–3, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4 spread globally. Countermeasures are needed to treat and prevent ...
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
2019-nCoV SARS-CoV ACE2 monoclonal antibody RBD
2020/6/12
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, how...
Prenatal undernutrition, postnatal environments, and antibody response to vaccination in adolescence
infantile diarrhea vaccine nutrition adolescents
2016/6/14
Recently, researchers have considered the fetal
and infant origins of several adult cardiovascular and metabolic
diseases, but the implications of early events for immune function
and infectious di...
Antibody Evolution Constrains Conformational Heterogeneity by Tailoring Protein Dynamics
flexibility nonlinear spectroscopy fluorscein molecular recognition
2016/5/24
The evolution of proteins with novel function is thought to start from precursor proteins that are conformationally heterogeneous. The corresponding genes may be duplicated and then mutated to select ...
Development of a Novel, Anti-idiotypic Monoclonal Anti-prolactin Antibody That Mimics the Physiological Functions of Prolactin
Prolactin Anti-idotypic Antibody Signal Transduction
2016/5/20
In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was c...
Preparation and Characterization of an Antibody Antagonist That Targets the Porcine Growth Hormone Receptor
Porcine Growth Hormone Porcine Growth Hormone Receptors Signalling Pathway Antagonist
2016/11/10
A series of antagonists specifically targeting growth hormone receptors (GHR) in different species, such as humans, rats, bovines, and mice, have been designed; however, there are currently no antagon...
Determination and Correlation of Anticardiolipin Antibody with High Sensitivity C- reactive Proteins and its Role in Predicting Short Term Outcome in Patients with Acute Coronary Syndrome
Acute coronary syndrome Anticardiolipin antibodies
2015/7/22
Anticardiolipin antibody (aCL) is considered to be an independent risk factor while high sensitivity C reactive protein (hsCRP) is an established marker for coronary artery disease. This study was con...
PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
SIMPL Transcriptional Co-Activator NF-kB
2015/5/25
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal...
Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes
Monoclonal Anti-idiotypic Antibodies (Mab2s) Porcine Hepatocytes
2016/5/18
B-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonis...
Asymmetries in Chickens from Lines Selected and Relaxed for High or Low Antibody Titers to Sheep Red Blood Cells
Chicken Asymmetry Selection Wattle Stress
2016/5/17
Wattle length, width, and area were measured to classify bilateral asymmetries in four lines of chickens. The lines were the S26 generation of White Leghorns selected for high (HAS) or low (LAS) respo...
Interaction between Leptospiral Lipopolysaccharide and Toll-like Receptor 2 in Pig Fibroblast Cell Line, and Inhibitory Effect of Antibody against Leptospiral Lipopolysaccharide on Interaction
Leptospiral Lipopolysaccharide Pig Fibroblast Cell Line Toll-like Receptor 2
2016/5/17
Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs_NCC1), and causes the expression of proinflammatory cytokines. However, the ...
Correlation between cytokine profile,antibody titre and viral load during sub-clinical chicken anaemia virus infection
chicken infectious anaemia virus cytokine real time-PCR viral load antibody titre immunosuppression
2015/4/17
The present work was carried out to investigate the correlation between viral load and the cytokine profile and virus specific antibody levels at five day intervals up to 25 days post infection (dpi) ...
Single-domain antibody fragments derived from heavy-chain antibodies: a review
single-domain antibody fragment heavy-chain antibody antigen-binding site
2015/4/15
Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents. Due to their unique ...
Investigations into the lymphocyte phenotypes and the presence of rheumatoid factor and antinuclear antibody in the peripheral blood of 515 dogs
CD4+/CD8+ ratio immune-mediated disease herniated disc canine C-reactive protein lymphocyte
2015/4/15
The levels of rheumatoid factor (RF), antinuclear antibody (ANA), and composition of peripheral lymphocyte subsets in 515 dogs were examined. Of these sample cases, 33 cases were diagnosed as immune-m...
Targeting treatment for colorectal cancer: the EGFR antibody story
Targeting treatment colorectal cancer
2015/4/13
Frequent overexpression of the epidermal growth factor receptor in colorectal cancer was the rationale for the development of anti-epidermal growth factor receptor antibodies. The development of the d...