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该文章由四川大学华西护理学院硕士生导师、华西护理创新研究中心/护理学四川省重点实验室王贯副研究员联合四川大学华西医院陈亿、欧阳亮、蒋婷婷等人合作完成，于2021年5月在Acta Pharmaceutica Sinica B（影响因子：11.614；中科院分区：医学1区；Top期刊）期刊上发表，于2022年1月被收录为ESI高被引文章。
为了给寡糖质量控制和分析研究提供方法参考，对1-（4-异丙基）苯基-3-甲基-5-吡唑啉酮(PPMP)衍生化试剂在液相色谱（HPLC）和电喷雾质谱（ESI-MS）技术分析寡糖中的应用进行研究。用PPMP试剂在氨水介质中对葡寡糖链进行衍生化，衍生化产物用RP-HPLC分离，ESI-MS分析。实验表明：在确定的衍生化条件下，PPMP和寡糖的衍生化主产物为单分子标记物，葡寡糖混合物的单分子PPMP衍生物...
用不同形态的镉培养液(氯化镉、硝酸镉、镉-EDTA、草酸镉和柠檬酸镉)对不同种类的蕨类植物(狗脊、舌厥、石松、瓦韦和石韦)进行培养。研究发现，镉在植物体不同部位的富集量是有差异的(富集量：根>茎>叶);对SEC-HPLC截取出的植物鳌合肽(PCs)研究表明，不同形态的镉能不同程度的诱发植物体中PCs的合成，从而PCs与Cd配位，降低镉的毒性，发现的配体主要为PC3，iso-PC3(βAla)和is...
Development of a UPLC-ESI-MS/MS Assay for 20(S)-Protopanaxadiol and Pharmacokinetic Application of Its Two Formulations in Rats
Pharmacokinetic Application Two Formulations Rats
2010/9/14
An ultra-performance liquid chromatography-electrospray tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed to investigate 20(S)-protopanaxadiol (PPD) pharmacokinetics in rats. Rat plasma s...
HPLC/ESI-Q-TOF MS鉴定淋巴癌患者尿液中的修饰核苷
HPLC/ESI-Q-TOF MS 修饰核苷 淋巴癌病人 尿液
2009/11/23
尿液修饰核苷反映了机体RNA的代谢速率及细胞增殖状况, 可以作为非常有发展潜力的肿瘤标志物进行研究. 尿液中的修饰核苷采用Oasis®HLB固相萃取柱进行纯化, 利用高效液相色谱与电喷雾质谱联用(HPLC-ESI-MS)、高分辨质谱(HRMS)及串联质谱(MS/MS)技术进行分离鉴定. 对淋巴癌患者尿中修饰核苷研究发现, 9种尿液核苷与标样的信息完全一致, 17种无标样的尿液修饰核苷也被鉴...
甘露糖磷酰氨基酸缀合物的ESI-MS研究
甘露糖磷酰胺缀合物 电喷雾质谱 裂解规律
2009/11/23
一系列全乙酰保护甘露糖-1-磷酰氨基酸酯缀合物的α构型和β构型异构体的ESI-MSn裂解规律研究表明, β构型异构体会出现一系列特征的m/z 433, 391, 371的碎片离子, 且［M-CH2CHCH3+Na］+碎片丰度较大. ［M-糖基+Na］+和［糖基+Na］+碎片相对丰度较小. α构型分子反之. 同时对全乙酰保护的［糖基+Na］+ m/z 353碎片离子进行三级碎裂, 其主要特征是消除C...
HPLC-UV-ESI-MSn法分离鉴定葛根素原料药中4种有关物质
puerarin related impurity HPLC-UV-ESI-MSn FTICR-MS 3’-hydoxypuerarin genistin-8-C-glucoside neopuerarin B neopuerarin A
2010/3/30
A rapid, accurate and simple HPLC-UV-ESI-MSn method was developed for the separation and characterization of related impurities in puerarin bulk drug. The molecular structures and mechanism for the fr...
Sialic acid and lysine as an internal standard substance, the ESI-MS fingerprinting of extracts of Compound Indigowoad Root Granule which from different origin was studied. The fingerprinting was obta...
2-(4-取代苯基)咪唑并[5,6-f]邻菲咯晽化合物的ESI-MSn研究
ESI-MSn 2-(4-arylphenyl)imidazo[4,5-f]-[1,10]phenanthroline compounds fragmentation
2010/3/30
The mass spectrometric behavior of six 2-(4-arylphenyl)imidazo[4,5-f]-[1,10]phenanthroline compounds were investigated by the electrospray inonization multiple stage mass spectrometry. The fragmentati...
ESI-MS/MS法鉴别环肽非对映异构体和碎裂机理的研究
ESI mass spectrometry cyclic peptides diastereomer distinguishing diastereomer
2010/3/30
The discrimination of four pairs of cyclic peptide diastereomers were successfully achieved by ESI-MS. The ratio of ions’ abundance ratios between A and B isomers in MS/MS spectra was defined as a par...
ESI-MS analytical method was employed to study extracts of unprocessed and processed Radix Paeoniae alba. The results of the experiments prove that different processed methods is making a certain diff...
The isoflavonoids from Iris tectorum were analyzed by electrospray ionization tandem mass spectrometry(ESI-MS/MS). Based on the information of pseudo molecular ions and daughter ions were obtained by ...
High performance liquid chromatography-electrospray ionization mass spectrometry(HPLC/ESI-MSn) was applied to analyze the chemical constituents from n-BuOH extract of Folium Isatidis. The data of rete...
丹参水溶性成分的HPLC-ESI-MSn研究
Radix Salvia miltiorrhizae water-soluble conpstituents HPLC-ESI-MSn
2010/3/30
The water-soluble conpstituents in Radix salviamilitiorrhizae were studied by HPLC-MSn. Seven compounds were identified comparing on retention time, m/z and MSn data. They are Salvianolic acid H or Sa...
磷酰化肽酯及小肽与氨基酸相互作用的ESI-MS研究
ESI-MS N-phosphoryl dipeptides(or methyl esters) amino acids non-covalent weak interaction
2010/3/30
The non-covalent interaction between a series of N-diisopropylphosphoryl dipeptides(or methyl esters) (DPP) and amino acids was studied by ESI-MS. The results show that aromatic rings to form π–π conj...