搜索结果: 1-9 共查到“知识库 理学 Hedgehog”相关记录9条 . 查询时间(0.083 秒)
Overlapping and distinct functions for Gli proteins: Key mediators of hedgehog signaling in cell specification during embryonic development
Signals embryonic tissue cell differentiation the central nervous system the pituitary gland the pancreas cells
2014/12/11
Hedgehog (Hh) signaling is important for patterning and cell differentiation within many embryonic tissues. Hh is expressed in the notochord and the floor plate and acts as a morphogen in patterning o...
Multiple roles for hedgehog signaling in zebrafish pituitary development
Hedgehog signals cell type morphogenesis Hh signal spinal cord ventral cells downstream transcription factor the protein
2014/12/11
Hedgehog (Hh) signaling is required in many developmental processes including overall growth, induction of various cell types and morphogenesis. One of the earliest discoveries regarding Hh signaling ...
Characterization Of The Zebrafish Umleitung (uml) Mutant: Essential Roles For The Transmembrane Protein Brother Of Cdo (Boc) In Regulating Hedgehog (Hh) Mediated Cell Differentiation And Neural Patterning
Biological sciences Axon guidance Hedgehog signaling Morphogen gradients Neural patterning Pituitary
2014/12/10
The secreted Hedgehog (Hh) molecule acts as a morphogen, mitogen, and cell survival factor during embryogenesis and during later growth and tissue homeostasis periods in vertebrates. Hh plays these di...
Sonic Hedgehog信号通路与内耳发育调控
Sonic Hedgehog信号通路 内耳 发育 听力障碍
2013/10/30
在内耳发育过程中, Sonic Hedgehog(Shh)信号通路参与确定了内耳的腹侧极性、螺旋神经元的诱导及毛细胞发育。Shh由菱脑底端分泌, 与顶端产生的Wnt相互拮抗, 共同调节内耳的背腹轴形成。Shh作为神经元细胞的促分裂因子, 能够直接促进螺旋神经元细胞的发育。Shh信号的激活可导致Tbx1对Ngn1的抑制减弱, 间接上调了Ngn1的表达, 调控内耳的神经形成过程。通过调节耳蜗前体细胞的...
Hedgehog信号通路与消化系统恶性肿瘤
Hedgehog 胃癌 结肠癌 胰腺癌
2012/7/20
消化系统恶性肿瘤严重威胁人类健康， 目前人们对此类恶性肿瘤的发生与发展机制还缺乏完整的认识。Hedgehog信号通路在胚胎发育、成熟器官形成及形态维持中扮演着重要角色。随着研究的进一步深入， 人们发现Hedgehog信号通路的异常激活参与多种消化系统恶性肿瘤的形成与发展， 例如胃癌、结肠癌、胰腺癌等。探讨Hedgehog信号通路在消化系统恶性肿瘤形成及发展中的作用将有助于消化系统恶性肿瘤发病的分子...
Hedgehog信号通路与脂肪形成
Hedgehog(Hh)信号通路 脂肪细胞 细胞分化
2012/7/20
Hedgehog(Hh)信号通路是从果蝇到人类都非常保守的信号通路， 在脊椎动物和非脊椎动物胚胎期多种组织器官的发育中发挥着重要作用。Hh信号通路的异常会导致疾病(先天性缺陷和癌症)的发生。近年的研究发现， Hh信号通路在脂肪生长发育中发挥重要作用， 激活Hh信号通路能特异性地抑制白色脂肪组织细胞的分化， 而对棕色脂肪组织细胞分化没有作用。该文综述了Hh信号通路在脂肪细胞分化中的作用及其分子机制，...
The Radial-Hedgehog Solution in Landau--de Gennes' theory
Radial-Hedgehog Solution Landau--de Gennes' theory
2010/12/10
We study the radial-hedgehog solution in a three-dimensional spherical droplet, with homeotropic boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. The radial-hedgeho...
二噁英引起斑马鱼下颌短小及其与Sonic Hedgehog基因的关联。
A Study on the Long-eared hedgehog, Hemiechinus auritus(Gmelin, 1770) (Mammalia: Insectivora) in Turkey
Hemiechinus auritus Karyology Mammalia Turkey
2010/4/1
Thirteen specimens of Hemiechinus auritus collected in Turkey were examined for external, cranial, karyological and phallic characteristics along with postnatal development. The karyotype of H. auritu...