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屈前辉课题组分别在《Structure》 & 《Immunity》上报道Patch1研究及EB病毒vGPCR研究（图）
屈前辉课题组 EB病毒 生物医学研究院 Hh信号 单分子荧光实验
2023/4/17
细胞表面跨膜蛋白Patched（Ptc1）介导的Hedgehog (Hh)信号传递是调控动物形态发生的重要通路，其功能失调往往导致机体发育异常，且与基底细胞癌等恶性肿瘤的发生密切相关。穿膜12次的Ptc1蛋白主要分布于初级纤毛上。当没有配体Hh存在时，Ptc1可以通过降低细胞膜中的固醇类分子水平来抑制Hh信号通路及下游基因的转录表达。感应到Hh信号后，Ptc1从初级纤毛中向纤毛基底部位迁移，并富集...
Demographic structure and genetic diversity of the endangered Bísaro pig: Evolution and current status
conservation genetic variation inbreeding pedigree analysis swine
2018/11/23
Bísaro pig, a local endangered swine breed, has gained popularity in the recent years. A complete pedigree was used to evaluate the population structure and investigate the current breed’s genetic var...
Genomic structure and expression of the porcine ACTC1 gene
actin, alpha cardiac muscle 1 mRNA pig transcription profiling RT-qPCR
2018/11/23
A partial cDNA (~1200 bp) of the porcine ACTC1 gene was identified in the subtracted foetal hind limb muscle cDNA library (44 days of gestation; using m. biceps femoris cDNA as the driver). Using spec...
oint Inversion of the 3D P Wave Velocity Structure of the Crust and Upper Mantle under the Southeastern Margin of the Tibetan Plateau Using Regional Earthquake and Teleseismic Data
3D P-wave velocity structure China seismic array detection Panxi region Chuan-Dian Block Daliangshan Block southeastern margin of Qinghai–Tibet Plateau
2018/4/10
The special seismic tectonic environment and frequent seismicity in the southeastern margin of the Qinghai–Tibet Plateau show that this area is an ideal location to study the present tectonic movement...
THE STUDY ON THE DURABILITY OF SUBMERGED STRUCTURE DISPLACEMENT DUE TO CONCRETE FAILURE
Durability Submerged Structure Displacement Concrete Failure
2016/10/14
Concrete structures that exposed to marine environments are subjected to multiple deterioration mechanisms. An overview of the existing technology for submerged concrete, pressure resistant, concrete ...
DESIGN OF 3D TOPOLOGICAL DATA STRUCTURE FOR 3D CADASTRE OBJECTS
3D topology data structure TEN 3D cadastre modelling
2016/10/14
This paper describes the design of 3D modelling and topological data structure for cadastre objects based on Land Administration Domain Model (LADM) specifications. Tetrahedral Network (TEN) is select...
Probing the Structure of Supported Membranes and Tethered Oligonucleotides by Fluorescence Interference Contrast Microscopy
Water Oligonucleotides Microscopy, Fluorescence Microscopy, Interference Membranes, Artificial Sensitivity and Specificity Surface Properties Models, Chemical Silicon Dioxide
2016/5/24
Fluorescence interference contrast microscopy (FLIC) is a powerful method to structurally characterize fluorescent objects with nanometer-scale resolution in the z direction. Here we use FLIC to chara...
Studies of the Electronic Structure of Metallocene-based Second-order Non-linear Optical Dyes
Electronic Structure Metallocene Second-order Non linear Optical Dyes
2016/5/23
This paper describes a simple orbital picture for understanding the optical transitions and the second-order nonlinear optical response of metallocene-based chromophores of the form metallocene-(pi-br...
The Electronic Structure of the Chromophore in Green Fluorescent Protein (GFP)
Electronic Structure Chromophore Green Fluorescent Protein GFP
2016/5/23
The chromophore responsible for the fluorescence from Green Fluorescent Protein (GFP) of the jelly fish Aequorea Victoria1,2 is formed in an autocatalytic, posttranslational cyclization and oxidation ...
Crystal Structure and Photodynamic Behavior of the Blue-emission Variant Y66H/Y145F of Green Fluorescent Protein
Animals Biological Transport Crystallography, X-Ray Green Fluorescent Proteins Hydrogen-Ion Concentration Luminescent Proteins Luminescent Proteins Luminescent Proteins Mutation Peptides Protein Folding Protons Scyphozoa Spectrometry,Fluorescence tructure-Activity Relationship Titrimetry
2016/5/23
The crystal structure of a blue emission variant (Y66H/Y145F) of the Aequorea victoria green fluorescent protein has been determined by molecular replacement and the model refined. The crystallographi...
Spectroscopic Study of Ser92 Mutants of Human Myoglobin:Hydrogen Bonding Effect of Ser92 to Proximal His93 on Structure and Property of Myoglobin
Carbon Monoxide Cyanides Escherichia coli Ferric Compounds Ferrous Compounds Histidine Humans Hydrogen Bonding Magnetic Resonance Spectroscopy Mutagenesis Myoglobin Myoglobin Oxygen Polymerase Chain Reaction Recombinant Fusion Proteins Serine Serine Spectrophotometr Spectrum Analysis, Raman Structure-Activity Relationship
2016/5/23
Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., & Shoenborn, B. ...
X-ray Crystal Structure of a Mutant Recombinant Human Myoglobin at 2.8Å Resolution
Humans Myoglobin Recombinant Proteins X-Ray Diffraction Protein Conformation Mutation Molecular Structure
2016/5/23
We have grown crystals in trigonal space group P 3 2 21 of a mutant human myoglobin, aquomet form, in which lysine at position 45 has been replaced by arginine and cysteine at position 110 has been re...
A High Precision Structure of a Bacteriochlorophyll Derivative,Methyl Bacteriopheophorbide a
RAMAN SPECTROSCOPY LIQUIDS INTERMOLECULAR INTERACTIONS ISOTOPIC DILUTION BAND SHIFT
2016/5/20
A High Precision Structure of a Bacteriochlorophyll Derivative,Methyl Bacteriopheophorbide a.
Multi-nuclear NMR Studies of DNA Hairpins:1. Structure and Dynamics of d(CGCGTTGTTCGCG)
GERMANIUM DETERMINATION HYDRIDE GENERATION INDUCTIVELY COUPLED PLASMA EMISSION SPECTROMETRY MEDICINAL PLANT
2016/5/20
The solution structure of the hairpin formed by d(CGCGTTGTTCGCG) has been examined in detail by a wide variety of NMR techniques. The hairpin was characterized by proton NMR to obtain interproton dist...
Structure-Based Analysis of the Initial Electron Transfer Step in Bacterial Photosynthesis: Electric Field Induced Fluorescence Anisotropy
Fluorescence Electric fields Electron transfer Transfer reactions Anisotropy
2016/5/20
The fluorescence intensity from randomly oriented, immobilized Rb. sphaeroides reaction centers at 77 K increases in the presence of an externally applied electric field. We have proposed that this in...