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Dissecting Proton Delocalization in an Enzyme’s Hydrogen Bond Network with Unnatural Amino Acids
Dissecting Proton Delocalization Enzyme’s Hydrogen Bond Network Unnatural Amino Acids
2016/5/25
Extended hydrogen bond networks are a common structural motif of enzymes. A recent analysis proposed quantum delocalization of protons as a feature present in the hydrogen bond network spanning a tria...
Quantum delocalization of protons in the hydrogen-bond network of an enzyme active site
ab initio path integral molecular dynamics enzyme hydrogen bonding nuclear quantum effects proton delocalization
2016/5/25
Enzymes use protein architectures to create highly specialized structural motifs that can greatly enhance the rates of complex chemical transformations. Here, we use experiments, combined with ab init...
A conserved water-mediated hydrogen bond network defines bosutinib’s kinase selectivity
Humans Water Quinolines Nitriles Aniline Compounds src-Family Kinases Amino Acid Substitution Conserved Sequence Substrate Specificity Hydrogen Bonding
2016/5/25
Kinase inhibitors are important cancer drugs, but they tend to display limited target specificity, and their target profiles are often challenging to rationalize in terms of molecular mechanism. Here ...
A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis.
ribosome-anchored chaperone network facilitates eukaryotic ribosome biogenesis
2015/12/11
Molecular chaperones assist cellular protein folding as well as oligomeric complex assembly. In eukaryotic cells, several chaperones termed chaperones linked to protein synthesis (CLIPS) are transcrip...
Overexpression of a Hyperpolarization-Activated Cation Current (Ih) Channel Gene Modifies the Firing Activity of Identified Motor Neurons in a Small Neural Network
gene expression neuronal network
2015/8/25
Genetic network identification using convex programming
Gene the network capture gene cell material biological process
2015/8/7
Gene regulatory networks capture interactions between genes and other cell substances, resulting in various models for the fundamental biological process of transcription and translation. The expressi...
ONTOLOGY-DRIVEN AND NETWORK–ENABLED SYSTEMS BIOLOGY CASE STUDIES
bioinformatics Integration of genomics
2015/5/27
With the progress in high-throughput technologies and bioinformatics in recent years, it is possible to determine to what extent genetic or environmental manipulation of a biological system affects th...
HAPPI: A Bioinformatics Database Platform Enabling Network Biology Studies
Database Genome Regulatory network
2015/5/26
The publication of the draft human genome consisting of 30,000 genes is merely the beginning of genome biology. A new way to understand the complexity and richness of molecular and cellular function o...
A Novel Network Biology Approach To Drug Target Selections
Network Biology Approach Drug Target Selections
2015/5/26
Conventional drug discovery focuses on single protein targets and follows a “sequence,
structure, and function” paradigm for selecting best protein targets to screen lead
chemical compounds. This es...
Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
Twist1 Etv5
2015/5/21
CD4 T helper cells control immunity to pathogens and the development of inflammatory disease by acquiring the ability to secrete effector cytokines. Cytokine responsiveness is a critical component of ...
The Fanconi anemia signaling network regulates the mitotic spindle assembly checkpoint
cancer mitosis cell division
2015/5/21
anconi anemia (FA) is a heterogenous genetic syndrome characterized by progressive bone marrow failure, aneuploidy, and cancer predisposition. It is incompletely understood why FA-deficient cells deve...
Neuronal avalanches of a self-organized neural network with active-neuron-dominant structure
Neuronal avalanches self-organized neural network active-neuron-dominant structure Neurons and Cognition
2012/5/3
Neuronal avalanche is a spontaneous neuronal activity which obeys a power-law distribution of population event sizes with an exponent of -3/2. It has been observed in the superficial layers of cortex ...
Epidemics on a stochastic model of temporal network
Epidemics stochastic model of temporal network Populations and Evolution
2012/5/2
Contacts between individuals serve as pathways where infections may propagate. These contact patterns can be represented by network structures. Static structures have been the common modeling paradigm...
Decorrelation of neural-network activity by inhibitory feedback
Decorrelation of neural-network inhibitory feedback Neurons and Cognition
2012/5/2
Correlations in spike-train ensembles can seriously impair the encoding of information by their spatio-temporal structure. An inevitable source of correlation in finite neural networks is common presy...
Optimal Channel Efficiency in a Sensory Network
Optimal Channel Efficiency Sensory Network Biological Physics
2012/5/3
We show that the entropy of the distribution of avalanche lifetimes in the Kinouchi-Copelli model always achieves a maximum jointly with the dynamic range. This is noteworthy and nontrivial because wh...