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Structural basis for RNA replication by the SARS-CoV-2 polymerase
2019-nCoV SARS-CoV-2 COVID-19 remdesivir favipiravir polymerase RdRP virus nsp12 nsp8
2020/6/11
Nucleotide analog inhibitors, including broad-spectrum remdesivir and favipiravir, have shown promise in in vitro assays and some clinical studies for COVID-19 treatment, this despite an incomplete me...
Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
A deep learning framework for modeling structural features of RNA-binding protein targets
learning framework modeling structural features RNA-binding protein targets
2016/1/22
RNA-binding proteins (RBPs) play important roles in the post-transcriptional control of RNAs. Identify-ing RBP binding sites and characterizing RBP bind-ing preferences are key steps toward understand...
Structural and Contextual Dimensions of Iranian Primary Health Care System at Local Level
Health Services Administration Organizational Structure Organizational Culture
2015/10/16
Background: In recent years, family physician plan was established as the main strategy of health system in Iran, while organizational structure of the primary health care system has remained the same...
Ventricular Tachycardia in the Absence of Structural Heart Disease
Ventricular tachycardia structurally normal heart
2015/8/5
In up to 10% of patients who present with ventricular tachycardia (VT), obvious structural heart disease is not identified. In such patients, causes of ventricular arrhythmia include right ventricular...
Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (Aldh3a1) as an adjuvant therapy for reversing cancer chemo-resistance
cyclophosphamide chemosensitivity structure activity relationships cell culture
2015/5/25
ALDH isoenzymes are known to impact the sensitivity of certain neoplastic cells toward cyclophosphamides and its analogs. Despite its bone marrow toxicity, cyclophos-phamide is still used to treat var...
Variable selection and structural discovery in joint models of longitudinal and survival data
Joint models Mixed effect selection Structural discovery Adaptive LASSO Gaussian quadrature EM algorithm
2015/5/21
Joint models of longitudinal and survival outcomes have been used with increasing frequency in clinical investigations. Correct specification of fixed and random effects, as well as their functional f...
Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
hydrogel biomaterial degradation multi-structure photopolymerization thiol-ene chemistry
2015/1/12
Hydrogels prepared from photopolymerization have been used for a variety of tissue engineering and controlled release applications. Polymeric biomaterials with high cytocompatibility, versatile degrad...
Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta
AFM Ultrastructure Genotype/phenotype D-periodic spacing Modulus Energy
2014/11/6
Type I collagen is the most abundant protein in mammals, and is a vital part of the extracellular matrix for numerous tissues. Despite collagen’s importance, little is known about its nanoscale morpho...
Historical, tactical and structural analysis of the 4:2 defensive play system in handball
HANDBALL DEFENSIVE PLAY SYSTEM DEVELOPMENT TACTICS
2013/10/1
This study aims to show how the 4-2 Defensive Play System in Handball has developed both tactically and structurally over time. Logically, since its first appearance in Czechoslovakia during the 1960s...
HIV prevention: Towards a “structural-plus” approach
HIV Prevention Structural Factors Development
2013/1/29
Lack of integration and coordination between HIV prevention programmes and developmental programmes explain why many countries have not been able to halt the epidemic, and others still have unacceptab...
Structural neuroimaging and neuropsychological correlates of a single case of focal central pontine myelinolysis: Intact memory function with decreased intellectual and motor functions
Central Pontine Myelinolysis Neuropsychology
2013/2/20
We report on the case of middle-aged right-handed woman with central pontine myelinolysis (CPM) revealed by high resolution structural T2-weighted FLAIR MRI imaging. There was a general flattening of ...
Magnetic Ordering: Some Structural Aspects.
Structural and Magnetic Phase Transitions in Ni-Mn-Ga Ferromagnetic Shape-memory Alloy Crystals
Magnetic Phase Transitions Ni-Mn-Ga Ferromagnetic Shape-memory Alloy Crystals
2009/12/28
Structural and Magnetic Phase Transitions in Ni-Mn-Ga Ferromagnetic Shape-memory Alloy Crystals.
The Thermal, Magnetic, and Structural Characterization of the Crystallization Kinetics of Fe88Zr7B4Cu1, an Amorphous Soft Magnetic Ribbon
Activation energy crystallization kinetics differential scanning calorimetry NANOPERM X-ray diffractometry
2009/12/28
The Thermal, Magnetic, and Structural Characterization of the Crystallization Kinetics of Fe88Zr7B4Cu1, an Amorphous Soft Magnetic Ribbon.