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Death associated lepidopteran DALP, and its mammalian ortholog Hic-5, act as negative regulators of muscle differentiation
Vertebrates muscle differentiation muscle cells trunk limbs satellite cells cell apoptosis molecular regulation gene
2014/12/11
During muscle differentiation in vertebrates, myoblasts initially form in somites and then migrate to proper locations in the trunk and limbs. Once there, these cells are faced with one of three choic...
Studies of the complex of ribosomal protein L1 with its binding site in 23S rRNA: Modification -interference, mutagenesis and crosslinking
Ribosomal proteins escherichia coli ribosomes the protein spiral protein
2014/12/11
Interaction of ribosomal protein L1 and the 23S rRNA plays an important role in both the structure and biological activity of the Escherichia coli ribosome. We have minimized the binding site for prot...
The role of the crumbs complex in vertebrate rod morphogenesis and its regulation by a novel FERM protein mosaic eyes
Zebrafish Mosaic eyes retinal texture protein complex crumbs protein cell polarity
2014/12/11
Mutations in zebrafish mosaic eyes result in the disrupted retina lamination and other abnormalities. The moe locus encodes a FERM protein. In this study I sought to determine in which molecular pathw...
Regulation of Notch signaling by the E3 ubiquitin ligase Cbl-b and its role in CD4+ T cell anergy
Cell life cycle T cell signal T cell activation and E3 ubiquitin ligase
2014/12/11
Notch signaling is an evolutionarily conserved pathway that mediates a variety of cell fate decisions. In the immune system, the Notch pathway plays an important role throughout the life of T cells. C...
The Conformational Gymnastics of the Escherichia Coli SecA Molecular Machine and its Interactions with Signal Sequences
SecA Signal sequences Molecular machines
2014/12/10
Protein secretion is a selective and regulated process that is essential in all organisms. In bacteria the preprotein translocase SecA, either free in the cytosol or associated with the SecYEG translo...
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid
L-ascorbic acid cardiometabolic traits confounding genetic variants reverse causation
2018/12/20
Background: Observational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and re...
Effect of mastication on lipid bioaccessibility of almonds in a randomized human study and its implications for digestion kinetics, metabolizable energy, and postprandial lipemia
almonds lipid bioaccessibility mastication mathematical model microstructure
2018/12/19
Background: The particle size and structure of masticated almonds have a significant impact on nutrient release (bioaccessibility) and digestion kinetics.
Polymorphism, Expression of Natural Resistance-associated Macrophage Protein 1 Encoding Gene (NRAMP1) and Its Association with Immune Traits in Pigs
Natural Resistance-associated Macrophage Protein 1 (NRAMP1) Polymorphism Expression Association
2016/5/17
Natural resistance-associated macrophage protein 1 encoding gene (NRAMP1) plays an important role in immune response against intracellular pathogens. To evaluate the effects of NRAMP1 gene on immune c...
Diversity of Butyrivibrio Group Bacteria in the Rumen of Goats and Its Response to the Supplementation of Garlic Oil
Butyrivibrio 16S rRNA Gene Diversity Garlic Oil Goat Rumen
2016/5/16
This study aimed to investigate the diversity of the Butyrivibrio group bacteria in goat rumen and its response to garlic oil (GO) supplementation as revealed by molecular analysis of cloned 16S rRNA ...
Cambridge, Mass. – January 28, 2014 – Scientists at Harvard University and the Marine Biological Laboratory (MBL) hope new understanding of the natural nanoscale photonic device that enables a small m...
Swine Leukocyte Antigen-DQA Gene Variation and Its Association with Piglet Diarrhea in Large White, Landrace and Duroc
SLA DQA Gene Genetic Polymorphism Piglet Diarrhea
2016/5/12
The swine leukocyte antigen class II molecules are possibly associated with the induction of protective immunity. The study described here was to investigate the relationship between polymorphisms in ...
Association of the Porcine Cluster of Differentiation 4 Gene with T Lymphocyte Subpopulations and Its Expression in Immune Tissues
Pig CD4 Polymorphisms T lymphocyte subpopulations Expression
2016/5/11
Cluster of differentiation 4 (CD4) is mainly expressed on CD4+ T cells, which plays an important role in immune response. The aim of this study was to detect the association between polymorphisms of t...
基于序列trnL-trnF和ITS的榉属系统发育与地理分布格局的初步分析
地理分布格局 分子系统发育 榆科 榉属
2014/2/23
榉属(Zelkova)是包含6个种的榆科小属, 呈东亚、西亚和南欧间断分布。该文基于DNA序列trnL-trnF和ITS构建了榉属的分子系统发育树, 大体上把此属分为3个分支, 分别对应东亚、西亚和南欧的种类, 与前人仅依据ITS序列的结果不同。生物地理的扩散和隔离分化分析(DIVA)表明, 榉属的原始祖先分布区可能是欧亚北温带, 包括了东亚、西亚和南欧的某个大的区域。分化过程以隔离分化为主要特征...
Cenozoic flora of western India and its significance in palaeoclimatic and palaeophytogeographic interpretation
megafossil Rajasthan Gujarat palaeoclimate phytogeography
2014/1/16
The Cenozoic flora of western India (Rajasthan and Gujarat) is adversely affected by the tectonic activity such as collision of the Indian subcontinent with the Eurasian plate which is responsible for...
New plants of Gnetales from Early Cretaceous of China, and its bearing on the early evolution of Ephedraceae and Welwitschiaceae in Gnetales
Early Cretaceous north China Spinobractea Latibractea Constrobilus
2014/1/16
The Gnetales are a higher group of Gymnosperms, but our current knowledge of the morphology of the early Gnetales is lacking. Most known specimens are fragmentary, which makes it difficult to elucidat...