搜索结果: 1-15 共查到“生物学 NF-κB”相关记录26条 . 查询时间(0.092 秒)
2022年3月31日,云南大学生物医药研究院和中国科学院动物研究所合作在Frontiers in Cell and Developmental Biology杂志在线发表了题为“KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adap...
2019年8月22日,国际学术期刊Molecular Cell在线发表了中国科学院分子细胞科学卓越创新中心(生物化学与细胞生物学研究所)杨巍维研究组的最新研究成果:“α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development”。该研究揭示了代谢物...
旨在证明α-倒捻子素可以缓解脂多糖(LPS)诱导的IEC-6细胞的炎症并揭示其机制。笔者在体外培养的IEC-6细胞中构建LPS诱导的炎症模型,并通过流式细胞术、酶联免疫吸附测定(ELISA)、定量PCR(Q-PCR)、蛋白印迹(Western blot)的方法检测α-倒捻子素对LPS诱导的炎症是否有缓解作用。结果表明,5 μmol·L-1的α-倒捻子素预处理可以显著降低LPS诱导的前列腺素E2(P...
浙江大学生命科学研究院夏总平实验室在PLoS Pathogens发表论文揭示HTLV-1病毒蛋白Tax激活宿主NF-κB信号通路的机制(图)
浙江大学生命科学研究院夏总平实验室 PLoS Pathogens HTLV-1病毒蛋白Tax激活宿主NF-κB信号通路
2016/4/20
2016年4月15日,浙江大学生命科学研究院夏总平实验室在PLoS Pathogens刊物 (影响因子为7.562)上在线发表题为“HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains”的研究论文。人T细胞...
Effect of Inhibition of S-Nitrosoglutathione Reductase on the NF-κB Pathway
I kappa B I kappa B kinase beta NF-kappa B
2015/5/25
S-nitrosoglutathione reductase (GSNOR) also known as glutathione- dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. GSNOR oxidizes long chain alcohols to an aldehyde with ...
中国科学院昆明植物研究所研究员谭宁华主持的“NF-κB信号转导途径的植物环肽RAs新类型小分子探针作用机制研究”(项目编号:91013002)国家自然科学基金重大研究计划培育项目,日前通过了国家自然科学基金委员会医学科学部的结题验收。
近日,国际学术期刊Clinical Cancer Research在线发表了中科院上海生科院营养所王慧研究组的最新研究论文:Japonicone A suppresses growth of Burkitt’s lymphoma cells through its effect on NF-κB。该研究组与上海第二军医大学药学院张卫东课题组合作从中药植物旋覆花(Inula japonica)提取物...
近日,国际学术期刊Clinical Cancer Research在线发表了中科院上海生科院营养科学研究所王慧研究组的最新研究论文:Japonicone A suppresses growth of Burkitt’s lymphoma cells through its effect on NF-κB。该研究组与上海第二军医大学药学院张卫东课题组合作,从中药植物旋覆花(Inula japonic...
研究重组创伤弧菌溶细胞素(rVvhA)对人单核细胞系(THP-1)NF-κB信号通路的影响。应用CCK-8法检测rVvhA对THP-1细胞增殖的抑制作用; 倒置显微镜和激光共聚焦显微镜观察rVvhA作用后细胞的形态学变化和细胞内NF-κB p65的核转移情况; 应用流式细胞仪和Westernblot检测rVvhA作用后细胞浆内和细胞核内NF-κB p65的表达情况; ELISA检测rVvhA作用于...
NF-κB信号通路与骨骼肌萎缩
骨骼肌 萎缩 NF-κB 信号通路
2012/7/20
骨骼肌萎缩发生于多种生理和疾病状态下, 如废用、衰老和慢性病。核因子-κB(NF-κB)信号通路包括NF-κB、抑制蛋白-κB(IκB)和IκB激酶(IKK), 它们在肌萎缩中起着重要作用, 能够引起肌肉蛋白质降解、诱导炎症、阻断损伤/萎缩后肌纤维的再生。NF-κB转录靶包括MuRF-1、YY1和MMP-9, 还可通过转录后机制调节MyoD。而且, 应用遗传操作小鼠模型已证明NF-κB还是防止骨骼...
NF-κB在细胞凋亡中的调节作用和应用前景
NF-&kappaB 细胞凋亡 肌肉嫩化
2011/8/16
核转录因子-κB(nuclear factor-kappa B,NF-κB)是细胞核内重要的转录调节因子,是细胞存活、细胞周期、细胞黏附和迁移的重要调节者。本文主要介绍了NF-κB在细胞凋亡中的作用,探讨了细胞凋亡与宰后肌肉嫩化的关系,并展望了NF-κB参与宰后肌肉嫩化过程的研究前景。
Sensitivity analysis of a computational model of the IKK-NF-κB-IκBα-A20 signal transduction network
Sensitivity analysis computational model IKK-NF-κB-IκBα-A20 signal transduction
2010/11/15
The NF-{\kappa}B signaling network plays an important role in many different compartments of the immune system during immune activation. Using a computational model of the NF-{\kappa}B signaling netw...
Linear noise approximation of noise-induced oscillation in NF-κB signaling network
Linear noise approximation noise-induced oscillation NF-κB signaling network
2010/11/15
NF-{\kappa}B, one of key regulators of inflammation, apoptosis, and differentiation, was found to have noisy oscillatory shuttling between the nucleus and the cytoplasm in single cells when cells are...
Novel statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling network
Novel statistical ensemble analysis simulating extrinsic noise-driven response NF-κB signaling network
2010/11/15
Cellular responses in the single cells are known to be highly heterogeneous and individualistic due to the strong influence by extrinsic and intrinsic noise. Here, we are concerned about how to model ...
Noise-induced oscillatory shuttling of NF-κB in a two compartment IKK-NF-κB-IκB-A20 signaling model
Noise-induced oscillatory shuttling NF-κB two compartment IKK-NF-κB-IκB-A20 signaling model
2010/11/15
NF-{\kappa}B is a pleiotropic protein whose nucleo-cytoplasmic trafficking is tightly regulated by multiple negative feedback loops embedded in the NF-{\kappa}B signaling network and contributes to di...