搜索结果: 1-15 共查到“生物学 genome”相关记录149条 . 查询时间(0.068 秒)
引导编辑系统（Prime editor, PE）作为目前应用灵活、前景广阔的新型基因组编辑工具，可以实现植物基因组任意碱基的替换以及小片段的插入和删除，并在与位点特异性重组酶耦合时展现出高效精准大片段定点插入的潜力。由于PE在植物中的编辑效率偏低，目前虽有多项研究通过不同策略来提升植物引导编辑系统的效率，但这些改进的引导编辑器依然存在位点偏好明显、普适性较差等问题，并且大多数优化集中在水稻和玉米等...
南京农业大学农学院《Nature Communications》发表万建民院士团队“Genome-Wide association studies identify OsWRKY53 as s key regulator of salt tolerance in rice”（图）
万建民 基因 分子机制 蛋白
2023/10/28
盐碱胁迫影响水稻的生长发育、存活率与最终产量。水稻耐盐碱是由多基因控制的复杂性状。研究水稻应对盐碱胁迫的关键基因及其调控网络，对于培育耐盐碱水稻品种具有重要科学意义和应用价值。2023年6月16日，国际著名期刊Nature Communications发表了万建民院士团队在水稻耐盐碱研究上的新进展。
卵母细胞和早期胚胎异常是造成女性不孕及试管婴儿反复失败的重要原因。已有研究证实，遗传因素在卵母细胞和早期胚胎异常中发挥重要作用。既往研究主要集中于大家系及近亲家系患者，且致病突变主要遗传自父母，展现为显性遗传或隐性遗传模式。然而，新发突变（De novo mutations，DNMs）在卵母细胞和早期胚胎异常中发挥怎样的作用尚不清楚。
2023年03月27日，上海市免疫学研究所陈磊研究员团队在Genome Research上发表了题为“Simultaneous profiling of host expression and microbial abundance by spatial meta-transcriptome sequencing”的研究论文。该研究首次开发了空间宏转录组测序及一体化的生物信息分析技术SMT(Spa...
The liver’s ability to regenerate itself is legendary. Even if more than 70 percent of the organ is removed, the remaining tissue can regrow an entire new liver.
Biological arms races are commonplace in nature. Cheetahs, for example, have evolved a sleek body form that lends itself to rapid running, enabling them to feast upon similarly speedy gazelles, the fa...
In Down syndrome cells, genome-wide disruptions mimic a senescence-like state（图）
唐氏综合症 细胞生物学 全基因组 破坏模仿 衰老样状态
2023/6/6
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Genome-wide identification of NF-YA gene family in cotton and the positive role of GhNF-YA10 and GhNF-YA23 in salt tolerance
全基因组分析 雷蒙德氏棉 亚洲棉 海岛棉 陆地棉
2024/5/17
本研究基于全基因组分析，在雷蒙德氏棉、亚洲棉、海岛棉和陆地棉基因组中分别鉴定得到16、16、31和29个NF-YA基因。通过进化树分析将NF-YA基因分为4个亚组。结构分析表明NF-YA基因在棉属进化过程中相对保守。荧光定量显示GhNF-YAs可能通过ABA和 MeJA的调控通路响应盐和干旱。VIGS沉默GhNF-YA10和GhNF-YA23的表达，能显著降低棉花对盐的抗性，表明这两个基...
New method opens the door to efficient genome writing in bacteria
bacterial cell editing bacterial genomes microbiome DNA sequencing ssDNA
2021/8/6
Biological engineers have devised a way to program memories into bacterial cells by rewriting their DNA. The new DNA writing technique, which the researchers call HiSCRIBE, is much more efficient than...
2021年5月3日，中国农业大学生物学院生物学院吴森课题组在Genome Research杂志上在线发表了题为“A HIT-trapping strategy for rapid generation of reversible and conditional alleles using a universal donor” 的研究论文。报道了一种新的基因定点突变策略，为规模化制备哺乳动物尤其是大...
Scientists report 6 novel variants in CRISPR-Cas12a in plants,expanding genome engineering（图）
report 6 novel variants CRISPR-Cas12a plants expanding genome engineering
2021/4/9
The research of plant scientist Yiping Qi at the University of Maryland focuses on innovative genome editing and engineering techniques in plants, with the goal of improving the efficiency o...
浙江大学生命科学研究院2021年1月7日周琦实验室在Nature、Genome Res和GigaScience同日发表三篇论文系统阐述动物性染色体多样性（图）
周琦 动物性染色体 性染色体演化
2022/10/26
性染色体从遗传上决定了两性之间截然不同的生殖器官发育命运和成年个体的外形差异，展现出许多与常染色体截然不同的基因组特点和演化模式，一直是生物学家追踪的研究对象。经典的性染色体演化理论认为，性染色体通常起源于一对古老的常染色体，为了防止性别决定基因在性染色体之间发生交换，性别决定座位之间通常不发生同源重组。这种重组抑制的代价是雄性特异的Y染色体，或者雌性特异的W染色体发生不可逆的退化，丢失了绝大多数...
Nature-inspired CRISPR enzymes for expansive genome editing（图）
CRISPR酶 基因组编辑 应用计算生物学 DNA序列
2023/6/19
In nature, bacteria use CRISPR as an adaptive immune system to protect themselves against viruses. Over the past decade, scientists have been able to successfully build upon that natural phenomenon wi...
Guacamole lovers,rejoice! The avocado genome has been sequenced（图）
Guacamole lovers avocado genome sequenced
2019/10/21
We now know the DNA of guacamole.Scientists have sequenced the avocado genome, shedding light on the ancient origins of this buttery fruit and laying the groundwork for future improvements to farming....
Researchers wirelessly manipulate gene, step toward reprogramming the human genome（图）
manipulate gene toward reprogramming human genome
2019/10/23
A new University at Buffalo-led study supported by NSF describes how researchers wirelessly controlled FGFR1 -- a gene that plays a key role in how animals grow from embryos to adults -- in lab-grown ...